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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures

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Fralick M, Schneeweiss S, Patorno E (2017) Risk of diabetic ketoacidosis after initiation of an SGLT2 inhibitor

Buysschaert M, Tennstedt D, Preumont V

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Berberine may potentiate glucose-lowering effects of diabetes medications, increasing hypoglycemia risk when combined with insulin, sulfonylureas, or meglitinides