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The responsible conclusion is not: Muscle loss is a myth. It is also not: GLP-1 medications cause sarcopenia. A more accurate conclusion is: Substantial weight loss can include lean-tissue loss

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Evidence of direct depletion: Weak Mechanistic plausibility via reduced intake: Moderate Symptoms of B12 Deficiency Neuropathy Fatigue Brain fog Macrocytic anaemia Persistent fatigue during GLP-1 therapy can have multiple causes, including caloric restriction and micronutrient shifts

Glucagon-like Peptide-1 Receptor Agonists and Fracture Risk: a Network Meta-Analysis of Randomized Clinical Trials