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it reflects genetic variation in satiety hormones, gut-brain signaling, and nutrient sensing

The main reason for this lies in the way these drugs affect the hypothalamus

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Cell, 166, 209221

The STEP clinical trials demonstrated that semaglutide injection produced weight reductions ranging from 5% to 22% depending on dosage, while participants receiving higher doses experienced significantly greater metabolic improvements

Its sales were only $63 million in 2015 as compared to $2.673 billion in sales for Victoza that same year [183, 184]