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Joint Council of Allergy, Asthma and Immunology

Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway

Gydesen S

Hosseinian FS, et al

10.1016/j.bioorg.2017.10.006 90 Sharifi-RigiA.HeidarianE.AminiS

Thanks for any thoughts, Kelly Since hormetic compounds display a U-shaped biphasic dose-response curve, meaning that at low/optimal doses they improve health and have a reverse tolerance effect (get more powerful with frequent use), but at high doses have detrimental effects, Im wondering whether or not many of the supplements on the market containing high doses of these compounds (Like EGCG, Curcumin, and Resveratrol) are dangerous