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These can be signs of cardiovascular strain or an adverse reaction that requires medical evaluation

This technology has been widely used in the treatment of skin diseases, enabling the delivery of antioxidants into the skin or using the inherent antioxidant properties of the microneedles to address oxidative stress-related skin conditions (208210)

Recognizing that the STEP-8 population may not fully represent the Greek obesity population, trial-based characteristics were reviewed and adapted using local epidemiological data and expert clinical opinion (e.g., smoking prevalence, hypertension, and diabetes distribution) to enhance relevance for the Greek setting

This sample was entirely distinct from participants in cross-sectional clinical study, as detailed in Supplementary Table 2