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Oral and topical glutathione are considered safer and effective options, while IV glutathione lacks strong evidence and carries risks

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Risk mitigation strategies include using appropriate doses based on research objectives, using gradual dose escalation for chronic studies, rotating injection sites to minimize local reactions, and providing clear instructions about possible side effects

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NCT05259033) was a 52 week, randomised, multicentre, open-label, parallel group, phase 3a trial