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Allergen immunotherapy should only be considered if a patient is unresponsive to conventional treatments, as this therapy carries the risk of anaphylaxis, a potentially life-threatening reaction

Methods This study is presented as a narrative review combining the authors clinical experience with supporting literature

Weight-based dosing provides a more individualized approach than flat-dose recommendations

Inhibition of PPAR leads to serum acylcarnitine accumulation [190], whereas hepatic PPAR activation induced by energy deprivation or fibrates is associated with an increase in the carnitine concentration and a decrease in serum acylcarnitine accumulation [191, 192]