That's a specific and meaningful distinction, even accounting for the fact that the evidence comes from cell studies rather than large clinical trials
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But it is worth noticing that this mechanism is squarely about connective-tissue matrix and redox balance in skin, precisely the domain in which the human evidence sits
PMID:22304503
Additionally, Cucurbitacin B (CuB) stimulates GLP-1 secretion via the bitter taste receptor TAS2R10 and, similar to Metformin, induces hypoglycemic effects in diabetic mice [194]
Research shows that curcumin supplementation lowers inflammatory markers, boosts antioxidant capacity, and enhances skin parameters by modulating oxidative stress pathways [62,63,64]