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In addition, cohort studies support that long-term usage of metformin decreases the risk of early-onset prostate cancer in age groups less than 65 [97]

Preliminary studies suggest it is well-tolerated, but long-term safety and potential neurologic impacts need further investigation

Additional studies utilizing exome/genome-wide sequence data in CVS, based on yet other hypotheses or exome-wide, may reveal additional associated genes

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approximately 1520% require dual-pathway activation for optimal weight loss and metabolic improvement