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NCHS Data Brief, No

Limited clinical data exist supporting L-carnitine's use in the management of mitochondrial dysfunction related to aging and apoptosis, AIDS-related dementia complex, drug-induced anemia, bipolar depression, cachexia, cardiovascular disease, dyslipidemia, dysthymic disorder, fatigue, drug-induced hepatotoxicity, intermittent claudication, migraine prophylaxis, muscle cramps, and drug-induced peripheral neuropathy

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Elfrink S., Bergin L

Mitochondrial DNA variation and cancer

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To study their role in ferroptosis in ER+ breast cancer models, we depleted AGPAT3 and FAR1 using siRNA SMARTpools or a CRISPR sgRNA approach and treated MCF-7 and T47D cells with palbocicilib, RSL3, or the combination in clonogenic assays (Fig