They are limited but demonstrate safety in the tested dose range
Doses greater than 0.4 mg/day should be avoided until the diagnosis of pernicious anemia is ruled out
Nutritional Deficiencies Rapid weight loss can sometimes lead to a decrease in the intake of essential vitamins and minerals
Statements Author contributions AN-S: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing original draft, Writing review and editing
In melanoma, CSE loss of expression accompanies the progression of the disease, being highly expressed in primary tumors and low expressed in metastatic lesions ( Cysteine degradation catalyzed by CAT and MST (Figure 1B) is not deeply explored in cancer, since MST is more enzymatically efficient at a pH higher than the physiological, thus the role of CBS and CSE is considered more relevant in cancer biology (92)
With this approval, Janssen is continuing to deliver on its promise to develop new, innovative solutions for underrecognized, vulnerable patient groups and is bold in going where others are not to provide solutions that address unmet need
