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EMA statement on ongoing review of GLP-1 receptor agonists (suicidal thoughts and self-harm signal)

Curr Cardiol Rep 25, 17591767 (2023).

However, emerging evidence suggests a potential link between GLP-1 therapy and altered pain perception, possibly through several mechanisms: 1- Neuroinflammation and Microglial Activation: GLP-1 receptors are expressed in the brainstem, spinal cord, and dorsal root ganglia, regions involved in pain modulation

Aromatase in the cerebral cortex, hippocampus, mid-brain: ontogeny and developmental implications