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Use of tourniquet falsely elevates serum calcium due to local increase in protein binding and acidosis leading to release of tissue calcium

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Given the complex mechanisms at play, it may be that in the overall population of adults with diabetes, GLP-1 RAs have minimal effects on GFR but may be more beneficial within specific subpopulations

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ET-1 antagonism: bosentan Bosentan, an ET-1 receptor antagonist, has been applied in the treatment of HAPH