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(2014) suggested that treatment of betaine ameliorates NAFLD in the mice fed with a high-fat diet possibly by restoring the methylation capacity by increasing the SAM/SAH ratio and thereby reversing the abnormal expression of the genes involved in lipid metabolism, such as FAS (fatty acid synthase), ACOX (acyl-CoA oxidase), PPAR (peroxisome proliferator-activated receptor alpha) in the liver

Trends Biochem Sci (2017) 42(8):62539

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