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Glucose mediated GLP-1 release happens in humans only in the proximal and distal small intestine and independently of ATP mediated potassium channels closure

Their large peptide structure (Figure 1) makes them prone to enzymatic degradation, lowering bioavailability, and can trigger immunogenicity causing anti-drug antibodies (ADAs)

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And yet the FDAs absence in regulating this marketing shift has allowed the line between healthcare and high-end consumerism to blur even further