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This imbalance might cause LPS to be increasingly produced and enter the bloodstream, triggering widespread inflammation through IL-10, disruptions in the HPA axis, and a reduction in cortisol levels, another factor linked with ME/CFS [79, 80]
We dont know whether the participants were B12 deficient and were being made B12 replete, or whether they were B12 replete to start with and this was additional B12, which would be important to know if you did think that this were an effective therapy. Dr Whittle said there were some effective pharmacotherapies for fibromyalgia such as duloxetine or pregabalin
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