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Phosphorylated Smad2/3 then form a complex with Smad4, which translocates to the nucleus to activate TGF- target genes, including -SMA, collagen, fibronectin, and MMPs [8] (Fig

[21] Systemic absorption of topical tretinoin is low, yet sporadic case reports have raised theoretical teratogenic concerns

2017 Sep 29;8:1239

Maddaloni G, Migliarini S, Napolitano F et al (2018) Serotonin depletion causes valproate-responsive maniclike condition and increased hippocampal neuroplasticity that are reversed by stress

368,369,370 HSF2 and DLG2 can block the oligomerization of ASC by interfering with the interaction between ASC and NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the upregulation of IL-1 expression and alleviating the inflammatory response

In that situation the responsible default is not assume it is fine unless proven harmful