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The acylation of ghrelin is required to activate the GHS-R and to mediate its effects on GH secretion and food intake.6 Ghrelin is mainly synthesized in the endocrine stomach cells and has a series of different biologic actions, including effects on glucose homeostasis, gut motility, pancreatic exocrine secretion, cardiovascular function, immunity and inflammation.7 The physiological relevance of these actions remains unclear, and the major role of the ghrelin seems to be exerted in the regulation of energy balance
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We see dramatic reductions in weight in patients taking these drugs
