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Collectively, these findings reveal that IRE1 negatively regulates cellular GSH availability and maintains cellular sensitivity to ferroptosis by dampening GCLC expression through its RIDD activity

A quality probiotic also supports the gut health changes that accompany both semaglutide use and dietary shifts

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In a study investigating human hepatocytes treated with fatty acids, exenatide was shown to reduce fatty acid storage and improve hepatocyte viability and markers of autophagy [10]