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At week 36, the 12mg group showed the most dramatic eating behavior changes: Perceived hunger decreased by 2.4 points versus placebo Disinhibition improved by 2.6 points Dietary restraint increased by 3.3 points 100% of participants achieved at least 5% body weight loss by week 48 83% achieved 15% or greater weight loss Mean weight reduction reached 24.2% at 48 weeks These numbers represent the strongest weight loss and appetite-related outcomes ever recorded in clinical trials for any GLP-1 class medication

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For standard-release tablets, the usual maintenance dose is 1,000 mg twice daily, with a maximum of 3,000 mg daily in divided doses (though many patients are maintained on 2,000 mg daily)

The insurer claimed that the drug was not medically necessary, and suggested diet and exercise instead

Case reports of in-utero exposure have documented feminizing effects on male fetuses