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Retatrutide is dosed once weekly by subcutaneous injection, titrated in 4-week steps from a 2 mg start through 4, 8 and 12 mg, with 12 mg being the maximum dose tested in the 2023 NEJM Phase 2 trial (24.2% mean weight loss at 48 weeks) [5][2]

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Administration of Bifidobacterium breve improves the brain function of A1-42-treated mice via the modulation of the gut microbiome