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The other major difference observed among AsGGT1, AsGGT2, and AsGGT3 is in their subcellular localization

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doi:10.1186/1743-7075-10-2

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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)