Yes, over-the-counter antacids, H2 blockers, and proton pump inhibitors are safe to use with semaglutide and do not interfere with its weight loss mechanism
This was confirmed by a randomised controlled trial (among endurance athletes) showing that fasting and post-meal ghrelin concentrations were lower and GLP-1 concentrations were higher on a ketogenic diet compared to high-carbohydrate diets (HCDs) and habitual diets (HDs)
| Substance | Receptor profile | Trial | Weight change | Placebo | | --- | --- | --- | --- | --- | | Retatrutide | GIP/GLP-1/glucagon | Phase 2 (48 wk) | -8.7 to -24.2 % | -2.1 % | | Tirzepatide | GIP/GLP-1 | SURMOUNT-1 (72 wk) | -16.0 to -22.5 % | -3.1 % | | Semaglutide | GLP-1 | STEP 1 (68 wk) | -14.9 % | -2.4 % | | Cagrilintide + semaglutide | Amylin + GLP-1 | Phase 1b (20 wk) | -15.7 to -17.1 % | -9.8 %* | | CagriSema | Amylin + GLP-1 | REDEFINE 1 (68 wk) | -20.4 % | -3.0 % | *Comparator arm semaglutide alone
Translation: The higher the dose and the faster you escalate the dose, the worse the gastrointestinal effects are going to be
At baseline, participants had: At 72 weeks , participants receiving the high-dose semaglutide + bimagrumab combination experienced: Thats a huge shift compared to the 60/40 or 75/25 ratios we see with GLP-1 monotherapy
However, it can cause steatorrhea, resulting in fat-soluble vitamin deficiency, and can even cause liver damage
