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We utilized WKY rats as a model for depression and assessed the antidepressant effects of ESC using the forced swim test

It helped slightly, often preserving lean mass or improving recovery, but it was the combined program that delivered measurable fat loss

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USA 113 , E4966E4975 (2016)

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25 A subsequent single-center placebo-controlled, multiple-ascending dose, phase 1b trial examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of cagrilintide in combination with semaglutide