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Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)

Neurosci Lett 662:227232 Pradhan G, Wu C-S, Lee JH, Kanikarla P, Guo S, Yechoor VK, Samson SL, Sun Y (2017) Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

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