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The topic becomes much more relevant when symptoms last longer than expected, feel stronger over time, or appear alongside a more complicated medical picture

High-Dose Tolerance A 7-day study demonstrated that doses as high as 700 mg silymarin three times daily (2,100 mg/day) could be given without causing adverse events (Hawke, J Clin Pharmacol, 2010) [14]

One of the most concerning issues that arise is their bioavailabilityand absorption after oral ingestion

If you are already taking thyroid medication (like Levothyroxine), certain supplementsincluding whey protein and isolated amino acidscan interfere with how the medication is absorbed

All current adult use is off-label, prescribed and dispensed through licensed compounding pharmacies

The Journal of Nutrition, Health & Aging, 16(5), 460-464