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studied the dose dependency of the gastrointestinal tolerability of D-allulose (Reference Han, Kwon and Yu40)

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Unlike older antidiabetic drugs [31,32,33], these drugs lower blood pressure and do not cause weight gain [34]

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Instead of occupying the orthosteric binding pocket where peptide or small molecule agonists generally bind, the high-resolution cryo-EM map demonstrates that compound 2 is covalently bonded to C347 6.36b (Wootten numbering in superscript 37 ) and mounted on the membrane-facing surface of the cytoplasmic end of TM6, providing solid structural evidence of a unique binding site for the ago-allosteric modulator (Fig