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Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet cells

doi: 10.1016/j.parkreldis.2009.05.005 [DOI] [PubMed] [Google Scholar] 95

A phase 1 study published in the Journal of the American College of Cardiology showed that a single subcutaneous dose of AMG 145 reduced LDL-C by up to 64% in statin-treated patients [4] with hypercholesterolemia