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Its utility was limited, however, because of an extremely short half-life in humans, but this problem had two solutions, both of which gave rise to important antidiabetic drugs: (1) orally active inhibitors of the enzyme dipeptidylpeptidase 4 (DPP-4 inhibitors), which was responsible for the rapid degradation

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The Arg82Cys polymorphism of the protein nepmucin implies a role in HDL metabolism

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Other compounds such as bile salts and xenobiotics (399), are known to be metabolized and excreted by the microbiota, affecting the host physiology