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Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic

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Reviews published in 2025 describe a body of research dominated by animal and cell studies, with signals suggesting effects on angiogenesis (the growth of blood vessels), growth-factor signalling (mainly growth hormone) and musculoskeletal healing

Rudy, B., Fishell, G., Lee, S

Before the meeting, the FDA's own scientific reviewers recommended against adding all four substances

Individual components are recognized nutrients, but that is not the same thing as an approved indication