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Physiological melanin hyperpigmentation is the result of increased melanin biosynthesis by melanocytes in the basal cell layer of the oral epithelium, but pathological melanin pigmentation may be the result of increased number of normal melanocytes or atypical melanocytes, of increased melanogenic activity of normal or atypical melanocytes, or of both

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The average crystallite sizes of CS NPs and the GSH-CS nanocomposite were calculated to be 25.4 nm and 17.1 nm, respectively, using the Sherrer equation (Fig

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