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N Engl J Med 385 , e4 (2021)

It enhances neuronal survival, promotes angiogenesis and synaptic plasticity, and modulates key neurotransmitter systems, including dopaminergic, serotonergic, and GABAergic pathways

Evidence suggests that antioxidant levels in the blood and brain of individuals under stress are altered several studies have also shown that an imbalance between overproduction of reactive oxygen species and antioxidant capacity plays a role in susceptible individuals

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In concert with the E2 ubiquitin-conjugating enzyme UBCH5a, glutathionylated OTUB1 interacts with SLC7A11 and prevents proteasomal degradation (Figure 4)

doi: 10.1007/s00262-020-02707-4 44 NeteaMGDomnguez-AndrsJBarreiroLBChavakisTDivangahiMFuchsEet al