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This phase IV clinical trial demonstrated that the combination of Sculptra (biostimulator) and Restylane products (hyaluronic acid fillers) delivered impressive results: Significant improvements in mid-face shape and contouring Enhanced skin quality, including significantly improving skin radiance and thickness Improved skin hydration maintained through follow-up visits High patient satisfaction, with 89% feeling more attractive and happier with their appearance The safety profile was excellent, with no treatment-related adverse events reported, confirming that these protocols are both effective and well-tolerated
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Extended Data Figure 6 Evaluation of the lipophilic hotspots on GLP-1R and interactions with peptide 5
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