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Shaking rather than gently swirling, using non-sterile water, or injecting directly onto the powder cake can all reduce effectiveness

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[3] Afamelanotide was also found to sometimes induce darkening of certain pre-existing skin conditions, so regular full body skin examinations every 6 months is often recommended

Some patients report noticing subtle changes within the first one to two weeks of a consistent protocol, though individual experiences vary widely and no specific outcomes are guaranteed

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