A recent 2025 study of more than 6,000 psoriasis patients with diabetes or obesity over a 2-year period, including 3,048 who were treated with GLP-1RAs and 3,048 who received other anti-diabetic or anti-obesity drugs, found that psoriasis patients treated with GLP-1RAs had a 78% lower risk of death and a 44% lower risk of major cardiovascular events compared to those taking other diabetes or weight-loss medications
The Core GLP-1 Mechanism GLP-1 Pathway Simplified Meal Intake Intestinal L-cells release GLP-1 GLP-1 binds GLP-1 receptors cAMP signaling Activation of PKA + PI3K/Akt pathways Multiple metabolic benefits Practical Clinical Effects In the Pancreas Insulin secretion from -cells Glucagon secretion from -cells Preservation of -cell mass Reduced -cell apoptosis In the Brain Appetite suppression Satiety enhancement Reduced food cravings In the Gastrointestinal Tract Delayed gastric emptying Reduced postprandial glucose spikes In Peripheral Tissues Improved glucose uptake Enhanced insulin sensitivity Reduced hepatic gluconeogenesis Evolution of GLP-1 Therapy: Historical Milestones Current Era Emergence of: Oral GLP-1 drugs Dual agonists Triple agonists Small-molecule GLP-1 therapies Current GLP-1 Agents Short-Acting Exenatide Lixisenatide Long Acting Liraglutide Dulaglutide Semaglutide Oral GLP-1 Oral semaglutide Orforglipron (new generation oral small-molecule GLP-1RA) Dual Agonists Tirzepatide (GLP-1 + GIP) Triple Agonists Retatrutide (GLP-1 + GIP + glucagon receptor) These newer agents are redefining obesity medicine and cardiometabolic care
I filled out the form, and within a few days, I had my prescription, Laura shared
Consider limiting fried foods, fatty cuts of meat, pastries, and creamy sauces if you notice they trigger or worsen nausea, cause prolonged feelings of uncomfortable fullness, or lead to reflux or indigestion
AnMBR in particular provides dual benefits: they decouple hydraulic and solids retention times, producing high-quality effluents suitable for reuse while concentrating biogas for more efficient utilization in combined CHP systems 90
Mental health is another area to watch
