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Preoperative management of endocrine, hormonal, and urologic medications: Society for Perioperative Assessment and Quality Improvement (SPAQI) consensus statement

It diminishes the expression of the cell cycle protein D1, enhances the expression of p27kip1, and activates c-Jun NH2-terminal kinase (JNK) (143)

Others are used off-label and have strong clinical evidence supporting their use for weight loss

Retatrutide does not yet have a confirmed recommended dose, as it is still in clinical trials

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Without a plan, its easy to unintentionally do too much, too soon, especially if symptoms seem mild