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Nausea usually eases with time at a held dose, while persistent constipation often requires separate management

Clark WH Jr, Elder DE, Guerry D, Epstein MN, Greene MH, Van Horn M

This imbalance can result from excessive cholesterol secretion by the liver, leading to supersaturation in bile, insufficient bile salts, or lecithin that fails to dissolve cholesterol effectively and impaired gallbladder motility that prevents proper emptying

Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo

Typically, the pathologic process involves the entire lobe or gland

It also plays a role in detoxification by conjugating with toxins to facilitate their excretion