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The liver alcohol dehydrogenase metabolizes the acetaldehyde of alcohol making this organ particularly susceptible to lesion (5, The brain is mainly composed of lipids, particularly docosahexaenoic acid (DHA) (22:6n-3), a n-3 long-chain polyunsaturated FA (PUFA), and eicosapentaenoic acid (EPA, 20:5n-3) and, at lower levels, by the omega-6 (n-6) arachidonic acid (AA) ( Compelling evidences have shown that n-3 protects against some brain conditions, such as multiple sclerosis, depression or schizophrenia (34), diminish oxidative stress (34, 35) and reduce neuronal death (35)

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The decrease in VIP distribution was proposed to be secondary to infection and inflammation