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Patients with a history of gastrointestinal issues including gastritis, acid reflux treated with PPIs, or any condition affecting stomach lining integrity already have compromised B12 absorption pathways

Nat Med 32 , 26622672 (2026)

What the Research Says: Key Studies Large-Scale Safety Data The STEP clinical trial program enrolled over 4,500 participants across multiple studies and did not identify hypothyroidism as a safety signal or adverse event of concern

Results showed that efinopegdutide was more effective in reducing LFC compared to semaglutide

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