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F2,6BP is a potent allosteric activator of the rate limiting enzyme of glycolysis, PFK-1, and an inhibitor of the gluconeogenic enzyme, fructose-1,6-bisphosphatase

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J Biol Chem (2013) 288(7):451321.10.1074/jbc.M112.402677 23 WangJHInoueTHigashiyamaMGuthPHEngelEKaunitzJDet alUmami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats

A single misstep during this process can lead to aggregation, peptide degradation, or complete loss of peptide function