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Symptoms can be categorised into local (injection site) and systemic manifestations, with varying degrees of severity

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More recent evidence utilizing a systems biology and metagenomics approach reveals NAFLD is likely to be a component of a more systemic disease, and the pathophysiology within the liver contributes significantly to overall progression.(4-9) Other organ systems include dysfunction of the adipose tissue, skeletal muscle, pancreas, intestine and central nervous system (Figure 1)