doi: 10.1016/j.neulet.2017.06.052 260 SotysK.TarczewskaA.BystranowskaD
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sativa mechanism is mainly because of its active ingredients, especially TQ (91,100)
Reduction of hyaluronan and collagen production in the TME by inhibition of the rate-limiting enzyme glutamine-fructosamidyltransferase 1 (GFAT1) of HBP leads to extensive remodeling of the ECM and increased levels of CD8(+) T infiltration, while enhancing PD1 treatment responses, eventually resulting in tumour regression (249, 250)
Additionally, LC can effectively cope with OS through a number of direct mechanisms (such as free radical scavenging and Fe2+ ion chelation) and indirect effects (due to ROS and RNS production of enzymes such as XO, NOX, and iNOS, while increasing the expression of GSH, SOD, CAT, and GPx antioxidants)
doi: 10.1021/acs.jmedchem.6b00669 81 QiYMaRLiXYLvSQLiuXYAbulikemuAet al