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The Healthcare Integrated Research Database (HIRD) as a Real-World Data Source for Pharmacoepidemiologic Research

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The elevation of plasma formaldehyde in the Aldh2*2 KI mice is considered to be caused by a combination of ALDH2 dysfunction and ADH5 downregulation in the liver, as the two enzymes are responsible for formaldehyde detoxification [89]

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Human Studies Because of ethical considerations, studies assessing the risks associated with maternal drug and chemical exposure in humans are strictly limited