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By examining the current literature, we will discuss the contribution of omics to unraveling the mechanisms underlying OA and how they may facilitate the development of new therapeutic strategies

We have recently argued that the extent of oxidative stress determines the severity with which diabetes presents itself (Kulkarni et al., 12 deficiency may be a major factor responsible for impaired GSH levels

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Toxics 12 , 294 (2024)

The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]

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