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Trial dosing follows a stepwise escalation from 12 mg up to maintenance doses of 4 mg, 8 mg, or 12 mg subcutaneously once weekly

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Although we sought to further elucidate the sources of heterogeneity, subgroup analyses based on sex, BMI, or other covariates could not be performed because too few studies and insufficient data were available

Most of these responses depend on the transactivation of epidermal growth factor receptor (EGFR) and its downstream targets phosphoinositide 3-kinase (PI3K)/serine-threonine-specific protein kinase B (also known as Akt) and extracellular signal-regulated kinases 1/2 (ERK 1/2) signaling pathways (Figure 2

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