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Presenter, 2024 VAHO Annual Meeting on National & Virginia Policy Opportunities & Threats to Quality Care, September 2024

10.1016/j.jhep.2008.04.026 J Hepatol

In fact, GLP-1 receptor agonists have a more favourable profile in terms of glycaemic control and body weight reduction, whereas in terms of hard clinical endpoints SGLT-2 inhibitors predominantly reduce hospitalisations for worsening HF and ameliorate progression of CKD, while GLP-1 receptor agonists may have more pronounced effects against myocardial infarction and ischaemic stroke [4]

More Complex Mechanism = More Complex Risks Activating two pathways may have unforeseen interactions GIPs role in gastrointestinal function not fully understood Potential for different or additional side effects beyond GLP-1 alone 3

The degree to which these medications impact these mechanisms needs to be studied more, he explained