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The foundational mechanism papers from the Washington State University lab that described how Dihexa works were retracted in April 2025 following a misconduct finding, with a third paper under an Expression of Concern since 2021

In contrast, CRTC2 binds indirectly to the promoter region via CREB1, and is significantly enriched during stimulation, functioning as the dominant transcription factor (Fig

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Graphical Abstract Similar content being viewed by others Introduction Inflammation and oxidative stress are common drivers of many chronic diseases, like cardiovascular diseases (CVD), diabetes, and cancer

Zhang, R.J

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