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Lipotoxicity refers to lipid metabolism disorders leading to an increase in FFA, excessive FFA makes pancreatic islet -cells dysfunctional, inducing them to produce a large amount of NO, causing a series of cytotoxic injuries

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Another trial on 1,210 people found similarly promising results, with those taking 2.4 mg of semaglutide reducing their body weight by 9.6% compared to 3.4% in the placebo group over 68 weeks of treatment

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SNO derived from erythrocytes also plays a key role in communicating with endothelial cells during hypoxia, promoting vasodilation through NO release