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4.4.2 Mechanistic hypotheses and clinical positioning Animal studies suggest that GLP-1RAs may restore ovulation by reducing local ovarian lipotoxicity and inflammatory/oxidative stress loads, thereby improving autophagy and PI3K/AKT/mTOR-related imbalances (131)

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219 Nicotine is another important consideration: though not found in significant amounts in food, nicotine has complex effects on neurotransmitter activity and negatively impacts sleep