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women planning pregnancy should stop GLP-1 medications at least 2 months before attempting to conceive

Retatrutide 64 mg is selected for extended protocols escalating to 8 mg or 12 mg weekly, matching the upper dose arms in Jastreboff et al

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32 A meta-analysis of randomized clinical trials of semaglutide also did not find an increased risk of acute pancreatitis compared with placebo (odds ratio 0.7, 95% confidence interval 0.51.2) regardless of dose, formulation (injectable or oral), or indication

doi: 10.1038/nrc2190

Long-term GLP-1 therapy has been studied in trials lasting over two years with established safety profiles